Cover letter
Dear Editor,
Journal of  Indonesiana Biomedical Science
January  25th, 2020
Previous observational studies aiming to identify the mechanism of Advance Platelet Rich Fibrin (A-PRF) + Hyaluronic Acid (HA) in Diabetic Foot Ulcer (DFU) healing. Little is known about the association HA and A-PRF with wound healing in DFU topical therapy. The current study aimed to investigate the influence of Hyaluronic Acid in Advance Platelet Rich Fibrin to reduce inflammation
Interestingly, we found that HA has an anti-inflammation and induce angiogenesis in DFU. Although A-PRF has also effect in angiogenesis, thus, these A-PRF effect is not adequate in inducing DFU granulation. In these study we find the good result of combine A-PRF +HA in DFU healing though angiogenesis and anti-inflammatory process, that show with analyzed of biomarker IL-6 and ImageJ software
We confirm that none of the material in the manuscript is included in another manuscript, has been published previously, or is currently under consideration for publication elsewhere. All authors have approved this manuscript and participated sufficiently in the work to take public responsibility for the content of this paper. If requested, we will provide the data or will cooperate fully in obtaining and providing the data. We did not receive any specific grant from funding agencies in the commercial, public, or not-for-profit sectors. We do not have any financial or non-financial potential conflicts of interest. Thank you for your consideration.
Sincerely,
Ronald Winardi Kartika, Prof Dr dr Idrus Alwi, Sp.PD KKV
Program Study Doctoral  Faculty of Medicine , Universitas Indonesia