Nutrigenetics, Nutrigenomics and Precision Nutrition

Anna Meiliana, Andi Wijaya

Abstract


BACKGROUND: Since our conception to death, we were permanently exposed to nutrition. Indeed, food intake is the key of the environmental factor that modulates our gene. Nutrigenomics focus on how common dietary chemicals altering an individual’s genetic makeup including genome, proteome, and metabolome. While nutrigenetics refer to how the genetic variation gives different responses to nutrients.

CONTENT: Nutrigenomics applied the high-throughput genomic-related tools to find out the influence of nutrients on the genes’ expression. While nutrigenetics (nutritional genetics) focus on the heterogenous response of gene variants to nutrients and dietary factors. Application nutrigenomics and nutrigenetics, integrated with system biology result in a precision nutrition as a relevant precise personal dietary change recommendation, thus will increase the motivation and sustain to whom the intervention is being delivered.

SUMMARY: Individual diet recommendation is not simple. Many factors and tools should be involved adequately. The application of integrated -omics approaches, together with nutrigenomic and nutrigenetics for novel biomarker discovering and precision nutrition tailoring were expected to develop a healthier lifestyle and behavior.

KEYWORDS: nutrigenetics, nutrigenomics, precision nutrition, metabolomics, system biology


Full Text:

PDF

References


Hyman M. Ultrametabolism: awaken the fat-burning DNA hidden in your body : the simple plan for automatic weight loss. New York; London: Atria Books; 2008.

DeBusk RM, Fogarty CP, Ordovas JM, Kornman KS. Nutritional genomics in practice: where do we begin? J Am Diet Assoc. 2005; 105: 589-98, CrossRef.

Kaput J, Rodriguez RL. Nutritional genomics: the next frontier in the postgenomic era. Physiol Genomics. 2004; 16: 166-77, CrossRef.

Mensink RP, Plat J. Post-genomic opportunities for understanding nutrition: the nutritionist’s perspective. Proc Nutr Soc. 2002; 61: 401-4, CrossRef.

van Ommen B, Stierum R. Nutrigenomics: exploiting systems biology in the nutrition and health arena. Curr Opin Biotechnol. 2002; 13: 517-21, CrossRef.

Ordovas JM, Mooser V. Nutrigenomics and nutrigenetics. Curr Opin Lipidol. 2004; 15: 101-8, CrossRef.

van Ommen B. Nutrigenomics: exploiting systems biology in the nutrition and health arenas. Nutr Burbank Los Angel Cty Calif. 2004; 20: 4-8, CrossRef.

Müller M, Kersten S. Nutrigenomics: goals and strategies. Nat Rev Genet. 2003; 4: 315-22, CrossRef.

Elliott R, Ong TJ. Nutritional genomics. BMJ. 2002; 324: 1438-42, CrossRef.

Trayhurn P. Nutritional genomics - “Nutrigenomics.” Br J Nutr. 2003; 89: 1-2, CrossRef.

Mathers JC. Nutrigenomics in the modern era. Proc Nutr Soc. 2017; 76: 265-75, CrossRef.

Neeha VS, Kinth P. Nutrigenomics research: a review. J Food Sci Technol. 2013; 50: 415-28, CrossRef.

Munshi A, Duvvuri S. Nutrigenomics: Looking to DNA for nutrition advice. Indian J Biotechnol. 2008; 7: 32–40, article.

Kaput J, Swartz D, Paisley E, Mangian H, Daniel WL, Visek WJ. Diet-disease interactions at the molecular level: an experimental paradigm. J Nutr. 1994; 124 (8 Suppl): 1296S-1305S, CrossRef.

Park EI, Paisley EA, Mangian HJ, Swartz DA, Wu MX, O’Morchoe PJ, et al. Lipid level and type alter stearoyl CoA desaturase mRNA abundance differently in mice with distinct susceptibilities to diet-influenced diseases. J Nutr. 1997; 127: 566-73, CrossRef.

Black SA. Diabetes, diversity, and disparity: what do we do with the evidence? Am J Public Health. 2002; 92: 543-8, CrossRef.

Boden G. Pathogenesis of type 2 diabetes. Insulin resistance. Endocrinol Metab Clin North Am. 2001; 30: 801-1, CrossRef.

Nathan DM. Initial management of glycemia in type 2 diabetes mellitus. N Engl J Med. 2002; 347: 1342-9, CrossRef.

Wellen KE, Hotamisligil GS. Inflammation, stress, and diabetes. J Clin Invest. 2005; 115: 1111-9, CrossRef.

Pavlidis C, Patrinos GP, Katsila T. Nutrigenomics: a controversy. Appl Transl Genomics. 2015;4: 50-3, CrossRef.

Nuno N, Heuberger R. Nutrigenetic associations with cardiovascular disease. Rev Cardiovasc Med. 2014; 15: 217-25, PMID.

Somvanshi PR, Venkatesh KV. A conceptual review on systems biology in health and diseases: from biological networks to modern therapeutics. Syst Synth Biol. 2014; 8: 99-116, CrossRef.

Jalili M. Network biology: Describing biological systems by complex networks: Comment on “Network science of biological systems at different scales: A review” by M. Gosak et al. Phys Life Rev. 2018; 24: 159-61, CrossRef.

Abhyankar V, Bland P, Fernandes G. The role of systems biologic approach in cell signaling and drug development responses: a mini review. Med Sci. 2018; 6: 43, CrossRef.

Kitano H. Computational systems biology. Nature. 2002 Nov; 420: 206-10, CrossRef.

Kitano H. Systems biology: a brief overview. Science. 2002; 295: 1662-4, CrossRef.

Ideker T, Galitski T, Hood L. A new approach to decoding life: systems biology. Annu Rev Genomics Hum Genet. 2001; 2: 343-72, CrossRef.

Ideker T, Thorsson V, Ranish JA, Christmas R, Buhler J, Eng JK, et al. Integrated genomic and proteomic analyses of a systematically perturbed metabolic network. Science. 2001; 292: 929-34, CrossRef.

Nicholson JK, Wilson ID. Opinion: understanding “global” systems biology: metabonomics and the continuum of metabolism. Nat Rev Drug Discov. 2003; 2: 668-76, CrossRef.

Watkins SM, German JB. Toward the implementation of metabolomic assessments of human health and nutrition. Curr Opin Biotechnol. 2002; 13: 512-6, CrossRef.

German JB, Roberts MA, Fay L, Watkins SM. Metabolomics and individual metabolic assessment: the next great challenge for nutrition. J Nutr. 2002; 132: 2486-7, CrossRef.

German JB, Roberts MA, Watkins SM. Personal metabolomics as a next generation nutritional assessment. J Nutr. 2003; 133: 4260-6, CrossRef.

Desiere F. Towards a systems biology understanding of human health: interplay between genotype, environment and nutrition. Biotechnol Annu Rev. 2004; 10: 51-84, CrossRef.

Hesketh J. Personalised nutrition: how far has nutrigenomics progressed? Eur J Clin Nutr. 2013; 67: 430-5, CrossRef.

Simopoulos AP. Nutrigenetics/Nutrigenomics. Annu Rev Public Health. 2010; 31: 53-68, CrossRef.

Nielsen DE, El-Sohemy A. A randomized trial of genetic information for personalized nutrition. Genes Nutr. 2012; 7: 559-66, CrossRef.

Noecker C, Borenstein E. Getting personal about nutrition. Trends Mol Med. 2016; 22: 83-5, CrossRef.

Betts JA, Gonzalez JT. Personalised nutrition: What makes you so special? Nutr Bull. 2016; 41: 353-9, CrossRef.

Ozdemir V, Suarez-Kurtz G, Stenne R, Somogyi AA, Someya T, Kayaalp SO, et al. Risk assessment and communication tools for genotype associations with multifactorial phenotypes: the concept of “edge effect” and cultivating an ethical bridge between omics innovations and society. Omics J Integr Biol. 2009; 13: 43-61, CrossRef.

Patrinos GP, Baker DJ, Al-Mulla F, Vasiliou V, Cooper DN. Genetic tests obtainable through pharmacies: the good, the bad, and the ugly. Hum Genomics. 2013; 7: 17, CrossRef.

Özdemir V, Kolker E. Precision Nutrition 4.0: A big data and ethics foresight analysis--convergence of agrigenomics, nutrigenomics, nutriproteomics, and nutrimetabolomics. Omics J Integr Biol. 2016; 20: 69-75, CrossRef.

Trujillo E, Davis C, Milner J. Nutrigenomics, proteomics, metabolomics, and the practice of dietetics. J Am Diet Assoc. 2006; 106: 403-13, CrossRef.

Subbiah MTR. Understanding the nutrigenomic definitions and concepts at the food-genome junction. Omics J Integr Biol. 2008; 12: 229-35, CrossRef.

Ferguson LR, De Caterina R, Görman U, Allayee H, Kohlmeier M, Prasad C, et al. Guide and position of the International Society of Nutrigenetics/Nutrigenomics on Personalised Nutrition: Part 1 - Fields of Precision Nutrition. J Nutr Nutr. 2016; 9: 12-27, CrossRef.

Fenech M, El-Sohemy A, Cahill L, Ferguson LR, French TAC, Tai ES, et al. Nutrigenetics and nutrigenomics: viewpoints on the current status and applications in nutrition research and practice. J Nutr Nutr. 2011; 4: 69-89, CrossRef.

Kaput J. Nutrigenomics research for personalized nutrition and medicine. Curr Opin Biotechnol. 2008; 19: 110-20, CrossRef.

Jones DP, Park Y, Ziegler TR. Nutritional metabolomics: progress in addressing complexity in diet and health. Annu Rev Nutr. 2012 Aug; 32: 183-202, CrossRef.

Fallaize R, Macready AL, Butler LT, Ellis JA, Lovegrove JA. An insight into the public acceptance of nutrigenomic-based personalised nutrition. Nutr Res Rev. 2013; 26: 39-48, CrossRef.

Remely M, Lovrecic L, de la Garza AL, Migliore L, Peterlin B, Milagro FI, et al. Therapeutic perspectives of epigenetically active nutrients. Br J Pharmacol. 2015; 172: 2756-68, CrossRef.

Martinez JA, Navas-Carretero S, Saris WHM, Astrup A. Personalized weight loss strategies-the role of macronutrient distribution. Nat Rev Endocrinol. 2014; 10: 749-60, CrossRef.

Gibney MJ, Walsh MC. The future direction of personalised nutrition: my diet, my phenotype, my genes. Proc Nutr Soc. 2013; 72: 219-25, CrossRef.

Martínez A. Perspectives on personalized nutrition for obesity. J Nutr Nutr. 2014; 7: I–III, CrossRef.

Juma S, Imrhan V, Vijayagopal P, Prasad C. Prescribing personalized nutrition for cardiovascular health: are we ready? J Nutr Nutr. 2014; 7: 153-60, CrossRef.

Bahcall O. Precision medicine. Nature. 2015; 526: 335, CrossRef.

Palou A. From nutrigenomics to personalised nutrition. Genes Nutr. 2007; 2: 5-7, CrossRef.

Bray MS, Loos RJF, McCaffery JM, Ling C, Franks PW, Weinstock GM, et al. NIH working group report-using genomic information to guide weight management: From universal to precision treatment. Obes Silver Spring Md. 2016; 24: 14-22, CrossRef.

Nielsen DE, Shih S, El-Sohemy A. Perceptions of genetic testing for personalized nutrition: a randomized trial of DNA-based dietary advice. J Nutr Nutr. 2014; 7: 94-104, CrossRef.

Nielsen DE, El-Sohemy A. Disclosure of genetic information and change in dietary intake: a randomized controlled trial. PloS One. 2014; 9: e112665, CrossRef.

Arkadianos I, Valdes AM, Marinos E, Florou A, Gill RD, Grimaldi KA. Improved weight management using genetic information to personalize a calorie controlled diet. Nutr J. 2007; 6: 29, CrossRef.

Kohlmeier M, Caterina RD, Ferguson LR, Görman U, Allayee H, Prasad C, et al. Guide and Position of the International Society of Nutrigenetics/Nutrigenomics on Personalized Nutrition: Part 2 - Ethics, Challenges and Endeavors of Precision Nutrition. Lifestyle Genomics. 2016; 9: 28-46, CrossRef.

Kussmann M, Fay LB. Nutrigenomics and personalized nutrition: science and concept. Pers Med. 2008; 5: 447-55, CrossRef.

Fay LB, German JB. Personalizing foods: is genotype necessary? Curr Opin Biotechnol. 2008; 19: 121-8, CrossRef.

Gillies PJ. Nutrigenomics: the Rubicon of molecular nutrition. J Am Diet Assoc. 2003; 103 (12 Suppl 2): S50-55, CrossRef.

Kohlmeier M, Kohlmeier GZ. Nutrigenetics applying the science of personal nutrition. Amsterdam: Elsevier/Academic Press; 2013, NLMID.

Rao AD, Sun B, Saxena A, Hopkins PN, Jeunemaitre X, Brown NJ, et al. Polymorphisms in the serum- and glucocorticoid-inducible kinase 1 gene are associated with blood pressure and renin response to dietary salt intake. J Hum Hypertens. 2013; 27: 176-80, CrossRef.

Ganesh V, Hettiarachchy NS. Nutriproteomics: a promising tool to link diet and diseases in nutritional research. Biochim Biophys Acta. 2012; 1824: 1107-17, CrossRef.

Kussmann M, Krause L, Siffert W. Nutrigenomics: where are we with genetic and epigenetic markers for disposition and susceptibility? Nutr Rev. 2010; 68 (Suppl 1): S38-47, CrossRef.

Panagiotou G, Nielsen J. Nutritional systems biology: definitions and approaches. Annu Rev Nutr. 2009; 29: 329-39, CrossRef.

Grimaldi KA, Look MP, Scioli GA, Clavero JC, Marinos S, Tagaris T. Personal genetics: regulatory framework in Europe from a service provider’s perspective. Eur J Hum Genet EJHG. 2011; 19: 382-8, CrossRef.

Hogart S. Regulation of genetic tests: an international comparison. In: Castle D, Ries NM, editors. Nutrition and Genomics: Issues of Ethics, Law, Regulation and Communication. 1st ed. Amsterdam: Elsevier; 2016. p.63-83, CrossRef.

de Toro-Martín J, Arsenault BJ, Després JP, Vohl MC. Precision nutrition: a review of personalized nutritional approaches for the prevention and management of metabolic syndrome. Nutrients. 2017; 9: 913, CrossRef.

Afman L, Müller M. Nutrigenomics: from molecular nutrition to prevention of disease. J Am Diet Assoc. 2006; 106: 569-76, CrossRef.

Davis CD, Milner J. Frontiers in nutrigenomics, proteomics, metabolomics and cancer prevention. Mutat Res. 2004; 551: 51-64, CrossRef.

Dunn WB, Bailey NJC, Johnson HE. Measuring the metabolome: current analytical technologies. The Analyst. 2005; 130: 606-25, CrossRef.

German JB, Roberts MA, Watkins SM. Genomics and metabolomics as markers for the interaction of diet and health: lessons from lipids. J Nutr. 2003; 133 (6 Suppl 1): 2078S-83S, CrossRef.

German JB, Bauman DE, Burrin DG, Failla ML, Freake HC, King JC, et al. Metabolomics in the opening decade of the 21st century: building the roads to individualized health. J Nutr. 2004; 134: 2729-32, CrossRef.

Ordovas JM, Corella D. Nutritional genomics. Annu Rev Genomics Hum Genet. 2004; 5: 71-118, CrossRef.

Goni L, Cuervo M, Milagro FI, Martínez JA. A genetic risk tool for obesity predisposition assessment and personalized nutrition implementation based on macronutrient intake. Genes Nutr. 2015; 10: 445, CrossRef.

Olsen NJ, Ängquist L, Larsen SC, Linneberg A, Skaaby T, Husemoen LLN, et al. Interactions between genetic variants associated with adiposity traits and soft drinks in relation to longitudinal changes in body weight and waist circumference. Am J Clin Nutr. 2016; 104: 816-26, CrossRef.

Qi Q, Chu AY, Kang JH, Jensen MK, Curhan GC, Pasquale LR, et al. Sugar-sweetened beverages and genetic risk of obesity. N Engl J Med. 2012; 367: 1387-96, CrossRef.

Brunkwall L, Chen Y, Hindy G, Rukh G, Ericson U, Barroso I, et al. Sugar-sweetened beverage consumption and genetic predisposition to obesity in 2 Swedish cohorts. Am J Clin Nutr. 2016; 104: 809-15, CrossRef.

Qi Q, Chu AY, Kang JH, Huang J, Rose LM, Jensen MK, et al. Fried food consumption, genetic risk, and body mass index: gene-diet interaction analysis in three US cohort studies. BMJ. 2014; 348: g1610, CrossRef.

Casas-Agustench P, Arnett DK, Smith CE, Lai CQ, Parnell LD, Borecki IB, et al. Saturated fat intake modulates the association between a genetic risk score of obesity and BMI in two US populations. J Acad Nutr Diet. 2014; 114: 1954-66, CrossRef.

Allison DB, Bassaganya-Riera J, Burlingame B, Brown AW, le Coutre J, Dickson SL, et al. Goals in nutrition science 2015–2020. Front Nutr. 2015; 2: 1–13, CrossRef.

Corella D, Coltell O, Mattingley G, Sorlí JV, Ordovas JM. Utilizing nutritional genomics to tailor diets for the prevention of cardiovascular disease: a guide for upcoming studies and implementations. Expert Rev Mol Diagn. 2017; 17: 495-513, CrossRef.

Srinivasan B, Lee S, Erickson D, Mehta S. Precision nutrition - review of methods for point-of-care assessment of nutritional status. Curr Opin Biotechnol. 2017; 44: 103-8, CrossRef.

Asher G, Sassone-Corsi P. Time for food: the intimate interplay between nutrition, metabolism, and the circadian clock. Cell. 2015; 161: 84-92, CrossRef.

Oike H, Oishi K, Kobori M. Nutrients, clock genes, and chrononutrition. Curr Nutr Rep. 2014; 3: 204-12, CrossRef.

Hill James O, Wyatt Holly R, Peters John C. Energy balance and obesity. Circulation. 2012; 126: 126-32, CrossRef.

Bouchard C, Blair SN, Church TS, Earnest CP, Hagberg JM, Häkkinen K, et al. Adverse metabolic response to regular exercise: is it a rare or common occurrence? PloS One. 2012; 7: e37887, CrossRef.

Sollid LM, Jabri B. Is celiac disease an autoimmune disorder? Curr Opin Immunol. 2005; 17: 595-600, CrossRef.

van Heel DA, West J. Recent advances in coeliac disease. Gut. 2006; 55: 1037-46, CrossRef.

Wieser H, Koehler P. The biochemical basis of celiac disease. Cereal Chem. 2008; 85: 1–13, CrossRef.

Jabri B, Kasarda DD, Green PHR. Innate and adaptive immunity: the yin and yang of celiac disease. Immunol Rev. 2005; 206: 219-31, CrossRef.

Trynka G, Wijmenga C, van Heel DA. A genetic perspective on coeliac disease. Trends Mol Med. 2010; 16: 537-50, CrossRef.

Calder PC, Albers R, Antoine JM, Blum S, Bourdet-Sicard R, Ferns GA, et al. Inflammatory disease processes and interactions with nutrition. Br J Nutr. 2009; 101 (Suppl 1): S1-45, CrossRef.

Calder PC. Fatty acids and inflammation: the cutting edge between food and pharma. Eur J Pharmacol. 2011; 668 (Suppl 1): S50-8, CrossRef.

Ferretti G, Bacchetti T, Masciangelo S, Saturni L. Celiac disease, inflammation and oxidative damage: a nutrigenetic approach. Nutrients. 2012; 4: 243-57, CrossRef.




DOI: https://doi.org/10.18585/inabj.v12i3.1158

Indexed by:

                 

                  

               

     

 

The Prodia Education and Research Institute