Serumal and Salivary 25(OH)D and 1,25(OH)D Levels of Head and Neck Cancer Patients

Dina Keumala Sari, Liza Meutia Sari, Lidya Imelda Laksmi, Farhat Farhat, Elvita Rahmi Daulay, Ferry Sandra, Zulfikar Lubis, Ratna Akbari Ganie

Abstract


BACKGROUND: Saliva has been suggested as a substitute of serum for the detection of 25 Dihydroxyvitamin D (25(OH)D) in healthy people. However, investigation of salivary 1,25(OH)D has not been clearly reported. Vitamin plays important roles in inhibiting cancer progression. Current study was conducted to investigate serumal and salivary 25(OH)D) and 1,25(OH)D levels of healthy and head and neck cancer (HNC) subjects.

METHODS: Research were conducted at Haji Adam Malik Hospital, Medan, Indonesia. Forty HNC and 40 healthy subjects were recruited and selected based on inclusion and exclusion criteria. Medical records were documented, followed by anthropometric evaluation and serum and saliva collection. Laboratory investigation for 25(OH)D and 1,25(OH) was performed using Enzyme-linked immunosorbent assay (ELISA) methods.

RESULTS: Significant serumal (p=0.002) and salivary (p=0.016) 25(OH)D mean level differences of HNC and normal groups were obtained. More serumal or salivary 25(OH)D deficient subjects were found in control group than those in HNC group. Meanwhile, serumal and salivary 1,25(OH)D mean levels of HNC group were not significantly different with the ones of control group. There were significant correlations of serumal-salivary 25(OH)D as well as serumal-salivary 1,25(OH)D levels in normal group.

CONCLUSION: Serumal and salivary 25(OH)D and 1,25(OH)D levels of HNC group were relatively normal. Salivary 25(OH)D and 1,25(OH)D could be suggested as substitutes for serumal ones.

KEYWORDS: vitamin D, 25(OH)D, 1,25(OH)D, head and neck cancer


Full Text:

PDF

References


Bochen F, Balensiefer B, Korner S, Bittenbring JT, Neumann F, Koch A, et al. Vitamin D deficiency in head and neck cancer patients - prevalence, prognostic value and impact on immune function. Oncoimmunology. 2018; 7: e1476817, CrossRef.

Mäkitie A, Tuokkola I, Laurell G, Mäkitie O, Olsen K, Takes RP, et al. Vitamin D in head and neck cancer: a systematic review. Curr Oncol Rep. 2020; 23: 5, CrossRef.

Huo M, Panizza B, Bernard A, Porceddu SV. Head and neck squamous cell carcinoma of unknown primary: Outcomes of a pre-defined institutional treatment policy in a region with a high prevalence of skin cancer. Oral Oncol. 2018; 77: 43-8, CrossRef.

Fanidi A, Muller DC, Midttun O, Ueland PM, Vollset SE, Relton C, et al. Circulating vitamin D in relation to cancer incidence and survival of the head and neck and oesophagus in the EPIC cohort. Sci Rep. 2016; 6: 36017, CrossRef.

Kelvianto A, Witjaksono F, Sekarutami SM. Protein intake, prognostic nutritional index and quality of life in head and neck cancer patients undergoing radiotherapy. Indones Biomed J. 2019; 11: 70-7, CrossRef.

American Cancer Society. Cancer Treatment & Survivorship Facts & Figures 2019-2021. Atlanta: American Cancer Society; 2019, article.

The Global Cancer Observatory [Internet]. Indonesia Globocan 2020 [cited 2021 Aug 20]. Available from: https://gco.iarc.fr/.

Pu Y, Zhu G, Xu Y, Zheng S, Tang B, Huang H, et al. Association between vitamin d exposure and head and neck cancer: a systematic review with meta-analysis. Front Immunol. 2021; 12: 627226, CrossRef.

Izreig S, Hajek M, Edwards HA, Mehra S, Sasaki C, Judson BL, Rahmati RW. The role of vitamin D in head and neck cancer. Laryngoscope Investig Otolaryngol. 2020; 5: 1079-88, CrossRef.

Yokosawa EB, Arthur AE, Rentschler KM, Wolf GT, Rozek LS, Mondul AM. Vitamin D intake and survival and recurrence in head and neck cancer patients. Laryngoscope. 2018; 128: E371-6, CrossRef.

Izzo M, Carrizzo A, Izzo C, Cappello E, Cecere D, Ciccarelli M, et al. Vitamin D: not just bone metabolism but a key player in cardiovascular diseases. Life (Basel). 2021; 11(5): 452, CrossRef.

Park CY, Han SN. The role of Vitamin D in adipose tissue biology: adipocyte differentiation, energy metabolism, and inflammation. J Lipid Atheroscler. 2021; 10: 130-44, CrossRef.

Zielinska A, Sobolewska-Wlodarczyk A, Wisniewska-Jarosinska M, Gasiorowska A, Fichna J, Salaga M. The 25(OH)D3, but not 1,25(OH)2D3 levels are elevated in IBD patients regardless of vitamin D supplementation and do not associate with pain severity or frequency. Pharmaceuticals (Basel). 2021; 14(3): 284, CrossRef.

Sari DK, Sari LM, Laksmi LI, Farhat. The moderate correlation between 25(OH)D serum and saliva in healthy people with low vitamin D intake. Int J Gen Med. 2021; 14: 841-50, CrossRef.

Bahramian A, Falsafi P, Abbasi T, Ghanizadeh M, Abedini M, Kavoosi F, et al. Comparing serum and salivary levels of vitamin d in patients with recurrent aphthous stomatitis and healthy individuals. J Dent Shiraz Univ Med Sci. 2018; 19: 295-300, PMID.

Kartikawati A, Lina Y, Wijaya A. 25(OH)D was Correlated with increased risk of insulin resistance, but not mediated by adiponectin and hsCRP. Indones Biomed J. 2012; 4: 84-92, CrossRef.

Weir CB, Jan A. BMI Classification Percentile And Cut Off Points. Treasure Island (FL): StatPearls Publishing; 2021, article.

Chiappin S, Antonelli G, Gatti R, De Palo EF. Saliva specimen: a new laboratory tool for diagnostic and basic investigation. Clin Chim Acta. 2007; 383; 30-40, CrossRef.

Heaney RP, Holick MF. Why the IOM recommendations for vitamin D are deficient. J Bone Miner Res. 2011; 26: 455-7, CrossRef.

Grant WB, Holick MF. Benefits and requirements of vitamin D for optimal health: a review. Altern Med Rev. 2005; 10: 94-111, PMID.

Augustin J, Outh-Gauer S, Mandavit M, Lépine C, Broudin C, Hans S, et al. [Study of the Human Papillomavirus (HPV) prevalence in head and neck carcinomas in a French monocentric cohort of 372 patients]. Ann Pathol. 2020; 40: 401-10, CrossRef.

Grant WB, Moukayed M. Vitamin D3 from ultraviolet-b exposure or oral intake in relation to cancer incidence and mortality. Curr Nutr Rep. Sep; 8: 203-11, CrossRef.




DOI: https://doi.org/10.18585/inabj.v13i4.1726

Indexed by:

                 

                  

               

  

 

The Prodia Education and Research Institute