Increased Platelet-derived Microparticles Counts is Correlated with Elevated Blood LDL Cholesterol in Acute Myocardial Infarction
Abstract
BACKGROUND: Platelet-derived microparticles (PDMPs) and low-density lipoprotein (LDL) cholesterol are contributing factors to acute myocardial infarction (AMI). However, the association between LDL cholesterol and PDMPs in AMI has not fully discovered. This study assessed the correlation between these two parameters in patients diagnosed with AMI.
METHODS: This was an observational cross-sectional study involving 95 subjects with AMI. The blood measurement of PDMPs counts and LDL cholesterol levels were conducted concomitantly within 24 hours of admission. PDMPs count was analyzed by flow-cytometry method, meanwhile the LDL cholesterol was measured with enzymatic and colorimetric methods. For further analysis, subjects were further divided into LDL cholesterol level ≥130 mg/dL and <130 mg/dL. A statistical test was conducted for a correlative and comparative analyses.
RESULTS: A correlative analysis to assess the association between PDMPs counts and LDL cholesterol level depicted a low but significant positive correlation (r=0.231, p=0.024). Furthermore, mean PDMPs counts was significantly higher in subjects with LDL cholesterol level ≥130 mg/dL compared to LDL cholesterol level <130 mg/dL (12,499.59 (95% CI: 8,507.44-16,491.74) counts/μL vs. 9,267.23 (95% CI: 4,445.45-14,089.01) counts/μL; p=0.039).
CONCLUSION: There was a significant correlation between PDMPs counts and LDL cholesterol levels in AMI. A significantly increased PDMPs counts were found in subjects with LDL cholesterol level ≥130 mg/dL. Therefore, it is recommended to measure PDMPs in patients with high LDL cholesterol levels as both might be significant AMI biomarkers.
KEYWORDS: acute myocardial infarction, LDL-cholesterol, platelet microparticles, platelet activation
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Setiawan W, Hartopo A, Rozqie R. Correlation between apolipoprotein B/apolipoprotein A-I ratio with atherogenic index of plasma among acute myocardial infarction patients. Indones Biomed J. 2018; 10(2): 179-83, CrossRef.
Reed GW, Rossi JE, Cannon CP. Acute myocardial infarction. Lancet. 2017; 389(10065): 197-210, CrossRef.
Anderson JL, Morrow DA. Acute myocardial infarction. N Engl J Med. 2017; 376(21): 2053-64, CrossRef.
Kementerian Kesehatan RI. Riset Kesehatan Dasar (RISKESDAS) 2013. Jakarta: Kementerian Kesehatan RI; 2013, article.
Kementerian Kesehatan RI. Riset Kesehatan Dasar (RISKESDAS) 2018. Jakarta: Kementerian Kesehatan RI; 2018, article.
Hartopo A, Puspitawati I, Gharini P, Setianto BY. Platelet microparticle number is associated with the extent of myocardial damage in acute myocardial infarction. Arch Med Sci. 2016 Jun 1; 12(3): 529-37, CrossRef.
Burnouf T, Goubran HA, Chou ML, Devos D, Radosevic M. Platelet microparticles: detection and assessment of their paradoxical functional roles in disease and regenerative medicine. Blood Rev. 2014; 28(4): 155-66, CrossRef.
Meiliana A, Wijaya A. Microparticles novel mechanisms of intracellular communication: implication in health and disease. Indones Biomed J. 2011; 3(1): 18-36, CrossRef.
Malekmohammad K, Bezsonov EE, Rafieian-Kopaei M. Role of lipid accumulation and inflammation in atherosclerosis: focus on molecular and cellular mechanisms. Front Cardiovasc Med. 2021; 8: 707529, CrossRef.
Meiliana A, Wijaya A. Novel biomarkers in cardiovascular disease: a review. Indones Biomed J. 2010; 2(3): 66-91, CrossRef.
Meiliana A, Dewi NM, Wijaya A. Advanced in molecular mechanisms of atherosclerosis: from lipids to inflammation. Indones Biomed J. 2018; 10(2): 104-22, CrossRef.
Hartopo AB, Mayasari DS, Puspitawati I, Mumpuni H. Circulating platelet-derived microparticles associated with postdischarge major adverse cardiac events in ST-elevation acute myocardial infarction. Cardiol Res Pract. 2020; 2020: 6721584, CrossRef.
Zuliani G, Volpato S, Dugo M, Vigna GB, Morieri ML, Maggio M, et al. Combining LDL-C and HDL-C to predict survival in late life: The InChianti study. PLoS One. 2017; 12(9): e0185307, CrossRef.
Huma S, Tariq R, Amin DF, Mahmood KT. Modifiable and non-modifiable predisposing risk factors of myocardial Infarction - A Review. J Pharm Sci Res. 2012; 4(1): 1649-53, article.
Sanchis-Gomar F, Perez-Quilis C, Leischik R, Lucia A. Epidemiology of coronary heart disease and acute coronary syndrome. Ann Transl Med. 2016 Jul; 4(13): 256, CrossRef.
Albrektsen G, Heuch I, Løchen ML, Thelle DS, Wilsgaard T, Njølstad I, et al. Lifelong gender gap in risk of incident myocardial infarction: The Tromsø Study. JAMA Intern Med. 2016; 176(11): 1673-9, CrossRef.
Khan HA, Alhomida AS, Sobki SH. Lipid profile of patients with acute myocardial infarction and its correlation with systemic inflammation. Biomark Insights. 2013; 8: 1-7, CrossRef.
Akosah KO, Cerniglia RM, Havlik P, Schaper A. Myocardial infarction in young adults with low-density lipoprotein cholesterol levels < or = 100 mg/dL: clinical profile and 1-year outcomes. Chest. 2001; 120(6): 1953-8, CrossRef.
Connolly KD, Willis GR, Datta DB, Ellins EA, Ladell K, Price DA, et al. Lipoprotein-apheresis reduces circulating microparticles in individuals with familial hypercholesterolemia. J Lipid Res. 2014; 55(10): 2064-72, CrossRef.
Mitsios JV TL, Dimitriou AA, Tselepis AD. Platelet-derived microparticles bind to low-density lipoprotein (LDL) in human plasma and reduce its susceptibility to oxidation. Hell J Atheroscler. 2016; 7(1): 36-50, article.
Nijiati M, Saidaming A, Guoqing L. In vitro study of the thrombogenic activity of platelet-derived microparticles from patients with acute coronary syndrome. Ann Clin Lab Sci. 2017; 47(2): 156-61, PMID.
Suades R, Padró T, Crespo J, Ramaiola I, Martin-Yuste V, Sabaté M, et al. Circulating microparticle signature in coronary and peripheral blood of ST elevation myocardial infarction patients in relation to pain-to-PCI elapsed time. Int J Cardiol. 2016; 202: 378-87, CrossRef.
Diah M, Rahmawati R, Lelo A, Muhktar Z, Lindarto D, Sandra F. Comparison of tumor necrosis factor-α level in coronary artery disease and coronary slow flow of thrombolysis in myocardial infarction. Indones Biomed J. 2019; 11(3): 299-303, CrossRef.
Tantawy AA, Matter RM, Hamed AA, Shams El Din El Telbany MA. Platelet microparticles in immune thrombocytopenic purpura in pediatrics. Pediatr Hematol Oncol. 2010; 27(4): 283-96, CrossRef.
Palasubramaniam J, Wang X, Peter K. Myocardial infarction-from atherosclerosis to thrombosis. Arterioscler Thromb Vasc Biol. 2019; 39(8): e176-e185, CrossRef.
Berezin AE, Berezin AA. Platelet-derived vesicles: diagnostic and predictive value in cardiovascular diseases. J Unexplored Med Data. 2019; 4: 4, CrossRef.
Rosadi I, Karina K, Rosliana I, Sobariah S, Afini I, Widyastuti T, et al. The effect of human platelet-rich plasma and L-ascorbic acid on morphology, proliferation, and chondrogenesis ability towards human adipose-derived stem cells. Mol Cell Biomed Sci. 2019; 3(1): 26-33, CrossRef.
Mentari D, Pebrina R, Nurpratami D. Utilization of expired platelet concentrate for production of human platelet lysate as a medium for T47D cell propagation. Mol Cell Biomed Sci. 2022; 6(2): 96-103, CrossRef.
Gąsecka A, Rogula S, Szarpak Ł, Filipiak KJ. LDL-cholesterol and platelets: insights into their interactions in atherosclerosis. Life (Basel). 2021; 11(1): 39, CrossRef.
Wang ZT, Wang Z, Hu YW. Possible roles of platelet-derived microparticles in atherosclerosis. Atherosclerosis. 2016; 248: 10-6, CrossRef.
Sargowo D, Sandra F. Combination of fibrinogen and high-sensitivity C-reactive protein measurements is potential in identification of acute coronary syndrome. Indones Biomed J. 2015; 7(1): 31-6, CrossRef.
Suades R, Padró T, Alonso R, Mata P, Badimon L. Lipid-lowering therapy with statins reduces microparticle shedding from endothelium, platelets and inflammatory cells. Thromb Haemost. 2013; 110(2): 366-77, CrossRef.
Badimon L, Suades R, Fuentes E, Palomo I, Padró T. Role of platelet-derived microvesicles as crosstalk mediators in atherothrombosis and future pharmacology targets: a link between inflammation, therosclerosis, and trombosis. Front Pharmacol. 2016; 7: 293, CrossRef.
de Man FH, Nieuwland R, van der Laarse A, Romijn F, Smelt AH, Gevers Leuven JA, et al. Activated platelets in patients with severe hypertriglyceridemia: effects of triglyceride-lowering therapy. Atherosclerosis. 2000; 152(2): 407-14, CrossRef.
DOI: https://doi.org/10.18585/inabj.v14i3.1892
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