Correlation of Oxidized-LDL, Resistin and Interleukin-1 Beta in Centrally Obese Men

Tri Nevita Margareth Panjaitan, Marita Kaniawati, Ilhamjaya Patellongi


BACKGROUND: Obesity is one of serious health problems, which increases the risks of cardiovascular disease, type 2 diabetes mellitus, and cancers. It is strongly associated with changes in the physiological function of adipose tissue, leading to altered secretion of adipokines and activation of inflammatory signaling pathways. This study was aimed to investigate the correlation of resistin, interleukin-1 beta (IL-1β), and oxidized low-density lipoprotein (OxLDL) in centrally obese men.

METHODS: The research was conducted with a crosssectional design involving 68 centrally obese men aged 31 to 60 years old, with waist circumference (WC) >90 cm. All subjects fulfilled the exclusion criteria. Anthropometric parameters, creatinine, estimated glomerular filtration rate (eGFR), serum glutamic oxaloacetic transaminase (SGOT), serum glutamic-pyruvic transaminase (SGPT), and high sensitivity C-reactive protein (hs-CRP) were measured. Serum concentrations of resistin, IL-1β and OxLDL were measured by enzyme-linked immunosorbent assay.

RESULTS: The study results showed there was a significant correlation of WC-OxLDL (r=0.235; p=0.030) and some correlation of WC-resistin (r=0.201; p=0.050). However, we observed no significant correlation of IL-1β-OxLDL (r=0.042; p=0.369), resistin-OxLDL (r=-0.072; p=0.285) and WC-IL-1β (r=-0.042; p= 0.367).

CONCLUSION: Our data show a relationship between WC and OxLDL, but the mechanism does not appear to be directly related to resistin or IL-1β.

KEYWORDS: resistin, IL-1β, OxLDL, atherosclerosis

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