Pro-inflammatory Profiles of Indonesian Adult Men with Central Obesity: A Preliminary Study on TNF-alpha, sTNFR-2 and IL-1beta
Abstract
BACKGROUND: Central obesity is closely associated with chronic inflammation, characterized by abnormal cytokine production such as IL-1β, tumor necrosis factor-α (TNF-α) and tumor necrosis factor receptor-2 (TNFR-2). Central obesity and chronic inflammation form a complex link with insulin resistance, leading to the development of type-2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). Knowing the coinciding occurrence of chronic inflammation and central obesity, this study aimed to examine pro-inflammatory cytokine profiles of Indonesian adult men with central obesity.
METHODS: This cross-sectional study recruited 80 apparently healthy Indonesian adult men, aged 23-53 years with waist circumference of 64-125 cm. This study was done in Jakarta. Measurements included clinical parameters like systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood glucose (FBG), aspartate amino transferase (AST), alanine amino transferase (ALT), creatinine, high sensitivity C-reactive protein (hsCRP), anthropometric parameters, namely weight, height and waist circumference; and pro-inflammatory cytokines TNF-α, soluble TNFR-2 (sTNFR-2) and IL-1β.
RESULTS: Basic characteristics of the subjects showed linear increase in values of SBP, DBP and the serum concentrations of AST, ALT, FBG, GFR, hsCRP (p<0.005, respectively) with the degree of obesity. sTNFR-2 and IL-1 β positively correlated with hsCRP (r=0.277, p=0.013 and r= 0.257, p=0.022, respectively), WC (r=0.380, p=0.001 and r=0.400, p<0.001, respectively) and body mass index (BMI) (r=0.364, p=0.001 and r=0.399, p<0.001, respectively). Moreover, TNF-α did not show correlations with hsCRP, WC and BMI.
CONCLUSION: There was a linear increase in the serum concentrations of sTNFR-2 and IL-1β in subjects with central obesity. Both pro-inflammatory markers, correlated with hsCRP, WC and BMI, but TNF-α did not. sTNFR-2 and IL-1β were, therefore, considered as valid biomarkers to indicate chronic inflammation in Indonesian adult men with central obesity.
KEYWORDS: central obesity, TNF-α, soluble TNFR-2 (sTNFR-2), IL-1β
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Witjaksono F. Body mass index and waist circumference among Indonesian adult from urban communities. Indonesian Society for the Study of Obesity (ISSO). [n.p.]: 3rd National Obesity Symposium (NOS III) 2004; 83-4.
Grundy SM. Metabolic syndrome: connecting and reconciling cardiovascular and diabetes worlds. J Am Coll Cardiol. 2006; 47: 1093-100, CrossRef.
Trayhurn P. White adipose tissue grafts--keeping in contact. AJP: Regulatory, Integrative and Comparative Physiology. 2005; 289: R297–8, CrossRef.
Sartika CR, Lukito W, Wijaya A. Hubungan antara inflamasi, stres oksidatif dan disfungsi endotel pada sindrom metabolik pria dewasa, kajian terhadap pemeriksaan biokimia: adiponektin total anti oksidan status dan hsCRP [thesis]. Makassar: Universitas Hasanuddin; 2006.
Trayhurn P, Wood IS. Adipokines: inflammation and the pleiotropic role of white adipose tissue. British J Nutr. 2004; 92: 347-55, CrossRef.
Wellen KE, Hotamisligil GS. Obesity-induced inflammatory changes in adipose tissue. J Clin Invest. 2003; 112: 1785-8, CrossRef.
Yudkin JS. Adipose tissue, insulin action and vascular disease: Inflammatory signals. Int J Obes Relat Disord. 2003; 27: S25-8, CrossRef.
Jager J, Gremeaux T, Cormont M, Marchand-Brustel YL, Tanti, JF. Interleukin-1gamma-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression. Endocrinology. 2007; 148: 241-51, CrossRef.
Hotamisligil GS. The role of TNFalpha and TNF receptors in obesity and insulin resistance. J Intern Med. 1999; 245: 621-5, CrossRef.
Good M, Newell FM, Haupt LM, Whitehead JP, Hutley LJ, Prins JB. TNF and TNF receptor expression and insulin sensitivity in human omental and subcutaneous adipose tissue – influence of BMI and adipose distribution. Diabetes Vasc Dis Res. 2006; 3: 26-33, CrossRef.
Hotamisligil GS. Mechanisms of TNF-alpha-induced insulin resistance. Exp Clin Endocrinol. 1999; 107: 119-125, CrossRef.
Qi C, Pekala PH. Tumor necrosis factor alpha induced insulin resistance in adipocytes. Soc Exp Biol Med. 2000; 223; 128-35, CrossRef.
Hube F, Hauner H. The role of TNF-alpha in human adipose tissue: prevention of weight gain at the expense of insulin resistance? Horm Metab Res. 1999; 31: 626-31, CrossRef.
Alberti KG, Zimmet P, Shaw J. IDF epidemiology task force consensus group: The metabolic syndrome: a new worldwide definition. Lancet. 2005; 366: 1059-62, CrossRef.
World Health Organization. Obesity: preventing and managing the global epidemic. Report of a WHO consultation on obesity. Geneva. 1997 Jun 3-5, article.
Sartika CR, Lukito W, Wijaya A. Adiponectin, total anti-oxidant status, and high sensitivity C-reactive protein in Indonesian men with metabolic syndrome. Med J Indonesia. 2009; 18; 262-8. CrossRef.
The National Kidney Foundation [homepage on the Internet]. New York: National kidney foundation-kidney disease outcomes quality initiative (NKF-KDOQI) guidlines; 2000 [cited 2007 August]. Avalibale from: www.kidney.org.
Chan DC, Watts GF, Barrett PHR, Burke V. Waist circumference, waist-to-hip ratio and body mass index as a predictors of adipose tissue compartments in men. Q J Med. 2003; 96: 441-7, CrossRef.
Ohkawa S, Odamaki M, Ikegaya N, Hibi I, Miyaji K, Kumagai H. Association of age with muscle mass, fat mass and fat distribution in non-diabetic haemodialysis patients. Nephrol Dial Transplant. 2005; 20: 945-51, CrossRef.
Packard RRS, Libby P. Inflammation in atherosclerosis: from vascular biology to biomarker discovery and risk prediction. Clin Chem. 2008; 54: 24-38, CrossRef.
Dinarello CA. Biology of interleukin 1. FASEB. 1998; 2: 108-15, PMID.
Stiehl DP, Jelkmann W, Wenger RH, Hellwig-Bürgel T. Normoxic induction of the hypoxia-inducible factor 1alpha by insulin and interleukin-1gamma involves the phosphatidylinositol 3-kinase pathway. FEBS Lett. 2002; 512: 157-62, CrossRef.
Diez-Ruiz A, Tilz GP, Zangerle R, Baier-Bitterlich G, Wachter H, Fuchs D. Soluble receptors for tumour necrosis factor in clinical laboratory diagnosis. Eur J Haematol. 1995; 54: 1-8, CrossRef.
Zahorska-Markiewicz B, Janowska J, Olszanecka-Glinianowicz M, Zurakowski A. Serum concentrations of TNF-α and soluble TNF-α receptors in obesity. Int J Obes Relat Disord. 2000; 24: 1392-5, CrossRef.
DOI: https://doi.org/10.18585/inabj.v2i1.112
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