Correlation of Progranulin, Granulin, Adiponectin and Vaspin with Metaflammation (hs-CRP) in Indonesian Obese Men
Abstract
BACKGROUND: Obesity is closely related to chronic, low grade systemic inflammation (metaflammation) and it leads to further metabolic complications such as hypertension, atherosclerosis, and type 2 diabetes due to the adipocytokine imbalance. This study was carried out to assess the correlation between progranulin, granulin, adiponectin and visceral adipose tissue-derived serine protease inhibitor (Vaspin) with metaflammation (high sensitivity C-reactive protein (hs-CRP)) in centrally obese men.
METHODS: This study was observational with a cross sectional design involving 60 men aged 30-60 years, consisted of 43 obese men (waist circumference (WC) ≥90 cm) and 13 non obese men (WC <90 cm), with no hypertension, and no renal dysfunction. Anthropometric parameters, creatinine, serum glutamic oxaloacetic transferase (SGOT), serum glutamic piruvic transferase (SGPT) and hs-CRP levels were measured. Serum concentrations of progranulin, granulin, adiponectin and Vaspin were measured by ELISA.
RESULTS: This study showed in obese men a significant correlation between hs-CRP and Vaspin (r=0.305; p=0.046), non-significant correlation between hs-CRP and progranulin (r=0.048; p=0.758), between hs-CRP and granulin (r=-0.223; p=0.150), also between hs-CRP and adiponectin (r=-0.121; p=0.439). Similar patterns were observed between adipokines level and WC. There were 3 patterns showing increase or decrease of adipokines value with WC between 80-86 cm; subsequently the pattern tended to become flat with WC between 86-105 cm, then showing increase or decrease of adipokines value with WC >105 cm.
CONCLUSION: We found metaflammation (hs-CRP) was significantly correlated with Vaspin, but not with progranulin, granulin and adiponectin, in obese men. We suggest the possibility of a dynamic expression of adipokines related to WC that are subjected to adipocytes hypertrophy-hyperplasia phenomenon.
KEYWORDS: progranulin, granulin, adiponectin, Vaspin, hs-CRP, metaflammation, central obesity
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Emanuela F, Grazia M, Marco de R, Maria Paola L, Giorgio F, Marco B. Inflammation as a link between obesity and metabolic syndrome.J Nutr Metab. 2012; 2012: 476380, CrossRef.
Okamoto Y, Kihara S, Funahashi T, Matsuzawa T, Libby P. Adiponectin: a key adipokine in metabolic syndrome. Clin Sci. 2006; 110: 267-78, CrossRef.
Youn BS, Bang SI, Klöting N, Park JW, Lee N, Oh JE, et al. Serum progranulin concentration may be associated with macrophage infiltration into omental adipose tissue. Diabetes. 2009; 58: 627-36, CrossRef.
Cenik B, Sephton CF, Kutluk Cenik B, Herz J, Yu G. Progranulin: A proteolytically processed protein at the crossroads of inflamation and neurodegeneration. J Biol Chem. 2012; 287: 32298-306, CrossRef.
Matsubara T, Mita A, Minami K, Hosooka T, Kitazawa S, Takahashi K, et al. PGRN is a key adipokine mediating high fat diet-induced insulin resistance and obesity through IL-6 in adipose tissue. Cell Metab. 2012; 15: 38-50, CrossRef.
Li Q, Chen R, Moriya J, Yamakawa J, Sumino H, Kanda T, et al. A novel adipokine, visceral adipose tissue-derived serine protease inhibitor (vaspin), and obesity. J Int Med Res. 2008; 36: 625-9, CrossRef.
Auguet T, Quintero Y, Riesco D, Morancho B, Terra X, Crescenti A, et al. New adipokines vaspin and omentin. Circulating levels and gene expression in adipose tissue from morbidly obese women. BMC Med Genet. 2011; 12: 60, CrossRef.
Koiou E, Kalaitzakis E, Tziomalos K, Mavridis S, Dinas K, Tantanasis T, et al. Vaspin: a novel adipokine, member of the family of serine protease inhibitors. Aristotle Univ Med J. 2011; 38: 7-18, article.
Rocha VZ, Folco EJ. Inflammatory concepts of obesity. Int J Inflam. 2011; 2011 :1-14, CrossRef.
Papizan, James B. Phosporylation of Fetuin-A. Physiological inhibitor of Insulin Action, Regulated by Insulin and Leptin. Alabama: Prostgraduate Program Universitas Auburn University; 2007.
Pearson TA, Mensah GA, Alexander RW. Markers of inflammation and cardiovascular disease: Application to clinical and public health practice a statement for healthcare professionals from the centers for disease control and prevention and the American Heart Association. Circulation. 2003; 107: 499-511, CrossRef.
Okura H, Yamashita S, Ohama T, Saga A, Yamamoto-Kakuta A, Hamada Y, et al. HDL/apolipoprotein A-I binds to macrophage-derived progranulin and suppresses its conversion into proinflammatory granulins. J Atheroscler Thromb. 2010; 17: 568-77, CrossRef.
Ong CH, Bateman A. Progranulin (granulin-epithelin precursor, PC-cell derived growth factor, acroganin) in proliferation and tumorigenesis. Histol Histopathol. 2003; 18: 1275-88, PMID.
Tang W, Lu Y, Tian QY, Zhang Y, Guo FJ, Liu GY, et al. The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice. Science. 2011; 332: 478-84, CrossRef.
Nathan C, Ding A. Nonresolving inflammation. Cell. 2010; 140: 871-82, CrossRef.
Tilg H, Hotamisligil GS. Nonalcoholic fatty liver disease: Cytokineadipokine interplay and regulation of insulin resistance. Gastroenterology. 2006; 131: 934-45, CrossRef.
Shehzad A, Iqbal W, Shehzad O, Lee YS. Adiponectin: Regulation of its production and its role in human diseases. Hormones. 2012; 11: 8-20, PMID.
Cho SH, Kwak SH, Lee Y, Moon MK, Lim S, Park YJ, et al. Plasma vaspin concentrations are elevated in metabolic syndrome in men and are correlated with coronary atheroscerosis in women. Clin Endocrinol. 2011; 75: 628-35, CrossRef.
Blüher M. Vaspin in obesity and diabetes: pathophysiological and clinical significance. Endocrine. 2012; 41: 176-82, CrossRef.
Marques BG, Hausman DB, Martin RJ. Association of fat cell size and paracrine growth factors in development of obesity. Am J Physiol. 1998; 275: 1898-908, PMID.
DOI: https://doi.org/10.18585/inabj.v5i2.59
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